Haloarylmalonamidooxacephalosporins

Details Haloarylmalonamidooxacephalosporins Haloarylmalonamidooxacephalosporins

C - Chemistry, Metallurgy

07

D

260/244.2

C07D 498/04 (2006.01) C07C 59/56 (2006.01) C07D 505/00 (2006.01)

Patent

CA 1100962

HALOARYLMALONAMIDOOXACEPHALOSPORINS ABSTRACT Antibacterial haloarylmalonamido-1-dethla-1-oxacephalosporins of the following formula: Image wherein Ar is Image , Image , Image , Image , Image or Image (in which Hal and Hal' each is halogen and RO is hydroxy or protected hydroxy); COA and COB each is carboxy or protected carboxy including a pharmaceutically acceptable salt group; and Het is 1-lower alkyl-5-tetrazolyl, 1,3,4-thiadiazol-2-yl or 5- lower alkyl-1,3,4-thiadiazol-2-yl, a pharmaceutical or veterinary composition comprising the said haloarylmalonamido-1-dethia-1-oxacephalosporin and pharmaceutical carrier, and a method for treating or preventing human or veterin- ary infectious diseases comprising administering the said antibac- terial compound.

300788

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