C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 39/21 (2006.01) A61K 31/05 (2006.01) A61K 31/405 (2006.01) A61K 31/4545 (2006.01) A61K 31/5377 (2006.01) C07D 413/02 (2006.01) C07F 9/59 (2006.01) C07F 9/6533 (2006.01)
Patent
CA 2582046
The invention relates to novel compounds denominated halocombstatins. The halocombstatins are derivatives of combretastatin A-3, and include compounds that exhibit cancer growth cell inhibition against a panel of human cancer cell lines and the murine P388 leukemia, as well as activity as inhibitors of tubulin polymerization and inhibitors of the binding of colchicine to tubulin.
L'invention porte sur de nouveaux composés appelés halocombstatines. Les halocombstatines sont des dérivés de la combretastatine A-3, et comprennent des composés qui présentent une inhibition de la prolifération des cellules cancéreuses contre un panel de lignées cellulaires cancéreuses humaines et la leucémie murine P388, et ont une activité comme inhibiteurs de la polymérisation des tubulines et comme inhibiteurs de la liaison de la colchicine à la tubuline.
Minardi Matthew D.
Pettit George R.
Rosenberg Heidi J.
Acti Ng For And On Behalf Of Arizona State University Arizona Board Of Regents A. Body Corporate Of The State Of Arizo
Borden Ladner Gervais Llp
LandOfFree
Halocombstatins and methods of synthesis thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Halocombstatins and methods of synthesis thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Halocombstatins and methods of synthesis thereof will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1879675