Halogenated 15-hydroxy-e-homoeburnane derivatives and a...

Details Halogenated 15-hydroxy-e-homoeburnane derivatives and a... Halogenated 15-hydroxy-e-homoeburnane derivatives and a...

C - Chemistry, Metallurgy

07

D

260/241.1

C07D 459/00 (2006.01) C07D 471/22 (2006.01)

Patent

CA 1137473

ABSTRACT OF THE DISCLOSURE The invention relates to new, racemic or optically active, halogenated 15-hydroxy-E-homoeburnane derivatives of the general formulae (Ia) and/or (Ib), Image (Ia) Image (Ib) wherein R is a C1-6 alkyl group and X is halogen, and acid addition salts thereof. These compounds are biologically active, furthermore they can be applied as intermediates in the synthesis of other pharmaceutically active substances. The compounds of the general formulae (Ia) and (Ib) are prepared by halogenating the respective racemic or optically active 15-hydroxy-E-homoeburnene derivative of the general formula (II), wherein R is as defined above. Image (II)

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