Halogenated derivatives of 1,3-dioxolane having mucolytic...

Details Halogenated derivatives of 1,3-dioxolane having mucolytic... Halogenated derivatives of 1,3-dioxolane having mucolytic...

C - Chemistry, Metallurgy

07

D

260/353

C07D 317/16 (2006.01) C07D 317/20 (2006.01) C07D 317/22 (2006.01)

Patent

CA 1064044

ABSTRACT OF THE DISCLOSURE: Halogenated derivatives of 1,3-dioxolane having the general formula: Image (I) wherein Rx is a linear or branched chain alkyl radical having 1 to 4 carbon atoms and bearing at least one bromine or iodine atom as a substituent, are obtained by condensing an acetal of the general formula: Image (II) wherein Rx has the afore said meaning and R is an alkyl radical having 1 to 3 carbon atoms, with 1-benzylglycerol in the presence of sulphosalicylic acid and catalytically hydrogenating the condensation product obtained. The compounds of formula (I) are useful as expectorants and fluidizers of tracheobronchial mucus.

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