Halogenated protease inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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260/311.3

C07D 263/10 (2006.01) C07C 45/46 (2006.01) C07C 49/807 (2006.01) C07C 63/70 (2006.01) C07C 63/74 (2006.01) C07C 65/01 (2006.01) C07C 65/32 (2006.01)

Patent

CA 1252106

ABSTRACT A novel compound of the formula: Image wherein R2 is halogen or trifluoromethyl; wherein R3 is -COR4, -CHOHR4, -C(CH3)OHR4, -CH2R4 or -CH=CHR4; wherein R4 is alkyl of 13 to 25 carbon atoms, inclusive; or a pharmacologically acceptable salt thereof. The compounds are useful as intermediates in the prepara- tion of the corresponding compounds of the formula: Image which are themselves useful for preventing or retarding the degradation of elastin or other proteins and therefore dis- ease states relating thereto.

521532

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