C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2565804
The present invention relates to methods for diagnosing or predicting responsiveness to treatment, such as Alefacept, by determining the presence of a nucleotide at one or more polymorphic sites within a haplotype marker. The present invention identifies multiple haplotypes that are associated with response to Alefacept. The haplotype markers identified by the present invention and methods of the invention can be particularly useful for diagnosing or predicting susceptibility to skin diseases, such as Psoriasis.
Cette invention concerne des procédés pour diagnostiquer ou prévoir la réponse à un traitement, par exemple un traitement Alefacept, en déterminant la présence d'un nucléotide sur un ou plusieurs sites polymorphes dans un marqueur haplotype. Cette invention identifie de multiples haplotypes associé à la réponse à un traitement Alefacept. Les marqueurs haplotypes identifié par cette invention et les procédés faisant l'objet de cette invention peuvent être particulièrement utiles pour diagnostiquer ou prévoir la sensibilité à des maladies de la peau, telles que le psoriasis.
Anant Madan Kamar
Dain Bradley J.
Koshy Beena
Zhan Ping
Genaissance Pharmaceuticals Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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