Hapten-carrier conjugates comprising virus like particles...

A - Human Necessities – 61 – K

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Details

A61K 39/385 (2006.01) A61K 47/48 (2006.01) C07K 14/005 (2006.01) C07K 14/02 (2006.01) C07K 14/08 (2006.01) C07K 14/195 (2006.01)

Patent

CA 2487849

The present invention provides compositions comprising a conjugate of a hapten with a carrier in an ordered and repetitive array, and methods of making such compositions. The conjugates and compositions of the invention may comprise virus like particles derived from eukayotic virus or bacteriophage as carriers, coupled to a variety of haptens, including hormones, toxins and drugs, especially drugs of addiction such as nicotine. Compositions and conjugates of the invention are useful for inducing immune responses against haptens, which can use useful in a variety of therapeutic, prophylactic and diagnostic regimens. In certain embodiments, immune responses generated using the conjugates, compositions and methods of the present invention are useful to prevent or treat addiction to drugs of abuse and the resultant diseases associated with drug addiction.

La présente invention concerne des compositions contenant un conjugué constitué d'un haptène et d'un porteur dans un jeu d'échantillons ordonné et répétitif. L'invention concerne également un procédé permettant de fabriquer de telles compositions. Les conjugués et les compositions décrits dans cette invention peuvent comprendre une large gamme d'haptènes parmi lesquels les hormones, les toxines et les drogues, plus particulièrement, les drogues créant une dépendance, telles que la nicotine. Les compositions et les conjugués décrits dans cette invention permettent de déclencher des réponses immunitaires contre les haptènes, ce qui peut être utile dans une large gamme de schémas thérapeutiques, prophylactiques et diagnostiques. Dans certains modes de réalisation, des réponses immunitaires produites au moyen des conjugués et des compositions et selon les modes de réalisation décrits dans cette invention permettent de prévenir ou de la toxicomanie ainsi que les maladies qui en découlent.

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