C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/16 (2006.01) A61K 39/385 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 14/00 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2352765
Novel hapten-carrier conjugates are capable of inducing the production of antibodies, in vivo, that speclfically bind to nicotine. These conjugates comprise a nicotine hapten conjugated to an immunogenic carrier protein. The novel conjugates preserve the chirality of nicotine in its native (S)-(-) state, and have good stability properties. The conjugates are useful in fonnuladng vaccines for active immunization, that are used to prevent and treat nicotine addiction. The antibodies raised in response to the nicotine hapten-carrier conjugate are used for passive immunization. These antibodies are administered for prevention and treatment of nicotine addiction.
L'invention concerne des conjugués haptène-porteur nouveaux capables d'induire la production d'anticorps, in vivo, se liant spécifiquement à la nicotine. Ces conjugués comprennent un haptène de la nicotine conjugué à une protéine vecteur immunogène. Ces nouveaux conjugués préservent la chiralité de la nicotine dans son état natif (S)-(-) et possèdent de bonnes propriétés de stabilité. Lesdits conjugués servent à formuler des vaccins pour une immunisation active, utilisés pour prévenir et traiter l'accoutumance à la nicotine. Les anticorps mobilisés en réponse au conjugué haptène-porteur de la nicotine sont utilisés pour l'immunisation passive. L'administration de ces anticorps permet de prévenir et de traiter l'accoutumance à la nicotine.
Ennifar Sofiane
Fattom Ali Ibrahim
Naso Robert B.
Nabi
Nabi Biopharmaceuticals
Smart & Biggar
LandOfFree
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