A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/385 (2006.01) A61K 35/12 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/21 (2006.01) A61K 39/00 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2222135
A novel composition comprising a hapten modified tumor cell extract prepared from cancer cells, or cancer cell membranes or peptides obtained therefrom is disclosed. Also disclosed are methods of treating cancer comprising administering therapeutically effective amounts of cyclophosphamide and hapten modified tumor cell extracts, with or without adjuvants and cytokines. Also disclosed is a method of screening for cytokine production by tumors in order to determine the efficacy of treatment, wherein cytokin-specific nucleic acids from a patient tissue sample are amplified in order to produce a detectable signal.
La présente invention concerne une nouvelle composition comprenant un extrait cellulaire tumoral à modification haptène préparé à partir de cellules cancéreuses ou de membranes ou peptides de cellules cancéreuses obtenus à partir de telles cellules. L'invention concerne également des procédé de traitement du cancer consistant en l'administration de quantités thérapeutiquement efficaces de cyclophosphamide et d'extraits cellulaires tumoraux à modification haptène, avec ou sans adjuvants et cytokines. L'invention concerne enfin un procédé de dépistage de production de cytokines par les tumeurs permettant de déterminer l'efficacité du traitement, lequel procédé consiste, pour produire un signal détectable, à amplifier les acides nucléiques spécifiques des cytokines dans un prélèvement tissulaire du patient.
Berd David
Eisenlohr Laurence C.
Lattime Edmund
Borden Ladner Gervais Llp
Thomas Jefferson University
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