Haptenated peptides and uses thereof

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 7/04 (2006.01) A61K 39/385 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/00 (2006.01) C07K 14/11 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2186873

MHC-binding carrier peptides linked to catechol derivatives are provided which are recognized by urushiol-specific T lymphocytes The compounds are useful in therapeutic compositions and methods for desensitizing individuals against contact sensitivity to haptens, such as urushiol of poison ivy/poison oak.

La présente invention concerne des peptides transporteurs se liant à l'antigène MHC, ces peptides présentant des liaisons avec des dérivés de la catéchine et étant reconnus par les lymphocytes T spécifiques de l'urushiol. Les composés sont utilisables pour les compositions et procédés thérapeutiques de désensibilisation des individus contre les sensibilisations par contacts avec l'haptine, tels que le sumac vénéneux ou le chêne vénéneux.

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