C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/765 (2006.01) C07D 401/04 (2006.01) C07D 405/14 (2006.01) G01N 33/52 (2006.01) G01N 33/53 (2006.01) G01N 33/94 (2006.01)
Patent
CA 2100265
2100265 9212975 PCTABS00014 Disclosed is a substantially optically pure hapten, useful in an immunoassay for cotinine. The hapten corresponds to a specified structural formula (I). In formula (I) X is a straight or branched chain, saturated or unsaturated, divalent radical covalently bonded to a pyridyl ring at the number 2-, 4-, 5- or 6- position. The divalent radical, X, has from 1 to 10 carbon atoms wherein the chain of the divalent radical optionally may contain 1 or 2 hetero atoms selected from members of the group consisting of S, O and NZ in which Z represents a C1 to C3 alkyl group. In formula (I), n = 1 or 0, and Q is a functional group selected from -COOH, -NH2 (provided that n does not equal 0), -C(O)NHNH2, -O(CO)Cl, -CHO, -NCS or -NCO. Also disclosed is an immunogen derived from the hapten as well as an antibody raised in response to an immunogen derived from the hapten. Also disclosed is a fluorescent tracer derived from a substantially optically pure compound corresponding to the hapten, the tracer being useful in an immunoassay for cotinine. Also disclosed is an improved immunoassay for determining cotinine in a biological sample involving a step of contacting the sample with antibodies raised in response to the immunogen. Also disclosed is a fluorescence polarization immunoassay (FPIA) for determining cotinine involving a step of contacting the sample with antibodies raised in response to the immunogen, and/or involving a step of contacting the sample with a fluorescent tracer.
Hasz Barbara E.
Hu Hsiang-Yun
Walling John A.
Abbott Laboratories
Swabey Ogilvy Renault
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