A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/13 (2006.01) A61K 9/107 (2006.01) A61K 9/48 (2006.01)
Patent
CA 2278675
The present invention provides a hard gelatine capsule containing a pharmaceutical composition comprising cyclosporin A in a mixture with a surfactant of HLB value at least 10, substantially free of any oil and when a hydrophilic phase is present, the hydrophilic phase being a polyethylene glycol and/or a lower alkanol provided that any lower alkanol present is present in less than 12 % of the total weight of the composition absent the hard gelatine capsule.
La présente invention concerne une capsule de gélatine dure contenant une composition pharmaceutique. Cette dernière comprend de la cyclosporine A dans un mélange avec un tensio-actif dont le rapport hydrophile-lipophile est d'au moins 10, sensiblement exempte d'huile. En présence d'une phase hydrophile, cette dernière est un glycole de polyéthylène et/ou un alcanol inférieur, à condition que la teneur d'alcanol présent soit inférieure à 12 % du poids total de la composition sans tenir compte de la capsule de gélatine dure.
Haeberlin Barbara
Meinzer Armin
Fetherstonhaugh & Co.
Novartis Ag
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