Harnessing network biology to improve drug discovery

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/02 (2006.01) C12Q 1/25 (2006.01) C12Q 1/68 (2006.01) C40B 30/00 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2590331

This invention provides principles, methods and compositions for ascertaining the mechanism of action of pharmacologically important compounds in the context of network biology, across the entire scope of the complex pathways of living cells. Importantly, the principles, methods and compositions provided allow a rapid assessment of the on-pathway and off-pathway effects of lead compounds and drug candidates in living cells, and comparisons of lead compounds with well-characterized drugs and toxicants to identify patterns associated with efficacy and toxicity. The invention will be useful in improving the drug discovery process, in particular by identifying drug leads with desired safety and efficacy and in effecting early attrition of compounds with potential adverse effects in man.

Cette invention porte sur des principes, des méthodes et des compositions permettant de déterminer le mécanisme d'action de composés importants d'un point de vue pharmacologique dans le contexte de réseaux biologiques, dans toute l'étendue des processus complexes des cellules vivantes. Cette invention porte tout particulièrement sur les principes, les méthodes et les compositions qui permettent d'évaluer rapidement les effets en cours de processus et hors processus des composés chefs de file et des candidats-médicaments dans les cellules vivantes et de comparer des composés chefs de file avec des médicaments et des substances toxiques bien caractérisés afin d'identifier des schémas associés à l'efficacité et à la toxicité. L'invention peut être utile pour améliorer le processus de la recherche médicamenteuse, notamment en identifiant les têtes de série pour médicaments présentant une sécurité et une efficacité souhaitées et en effectuant une attrition préalable des composés ayant des effets secondaires potentiels chez l'homme.

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