Harp family growing factors, preparation methods and uses...

Details Harp family growing factors, preparation methods and uses... Harp family growing factors, preparation methods and uses...

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/18 (2006.01) C07K 7/08 (2006.01) C07K 14/475 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2156850

A peptide having a similar sequence to peptide HARP and a mass of 18 kD. The N-terminal end of said peptide has one of the following sequences: NH2-ALA-GLU-ALA-GLY-LYS-LYS-GLU-LYS-PRO-GLU-LYS-LYS; NH2-ALA-VAL-ASP-THR-ALA-GLU-ALA-GLY-LYS-LYS-GLU-LYS-PRO-GLU;LYS-LYS. Said peptide or fragments thereof may be prepared by a genetic engineering method wherein vectors carrying at least part of the cDNA of the extended form of peptide HARP are expressed then extracted. Various therapeutical uses are disclosed.

Peptide présentant une similarité de séquence avec le peptide HARP et ayant une masse de 18 kD, caractérisé en ce que son extrémité N-terminale présente l'une des séquences suivantes: NH2-ALA-GLU-ALA-GLY-LYS-GLU-LYS-PRO-GLU-LYS-LYS, NH2-ALA VAL-ASP-THR-ALA-GLU-ALA-GLY-LYS-LYS-GLU-LYS-PRO-GLU-LYS-LYS. Ce peptide - ou ses fragments - peut être obtenu par un procédé d'ingénierie génétique, selon des vecteurs portant au moins portant au moins une partie d'un ADN complémentaire de la forme allongée du peptide HARP sont exprimés et ensuite extraits. Applications diverses en thérapeutique.

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