Hasylated polypeptides, especially hasylated erythropoietin

Details Hasylated polypeptides, especially hasylated erythropoietin Hasylated polypeptides, especially hasylated erythropoietin

C - Chemistry, Metallurgy

07

K

C07K 14/505 (2006.01) A61K 38/18 (2006.01) A61K 47/48 (2006.01) C07K 14/53 (2006.01) C07K 14/54 (2006.01) C07K 14/55 (2006.01) C07K 14/56 (2006.01) C07K 14/565 (2006.01) C07K 17/06 (2006.01) C07K 17/10 (2006.01) C08B 31/00 (2006.01) C12N 15/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2495242

The present invention relates to hydroxyalkylstarch (HAS)-polypeptide- conjugate (HAS-polypeptide) comprising one or more HAS molecules, wherein each HAS is conjugated to the polypeptide via a carbohydrate moiety or a thioether as well as to methods for the production thereof. In a preferred embodiment, the polypeptide is erythropoietin (EPO).

Cette invention, qui a trait à un conjugué d'hydroxy/alkyle/amidon (HAS) et de polypeptide (polypeptide-HAS) renfermant une ou plusieurs molécules de HAS dont chacune est conjuguée au polypeptide par une fraction glucidique ou un thioéther, concerne également des procédés permettant sa production. Dans un mode de réalisation préféré, ce polypeptide est de l'érythropoïétine (EPO).

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