Hbsag escape mutant vaccine

Details Hbsag escape mutant vaccine Hbsag escape mutant vaccine

A - Human Necessities

61

K

A61K 39/29 (2006.01) C07K 14/02 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2067003

55/JWW25 18347 TITLE OF THE INVENTION HBsAg ESCAPE MUTANT VACCINE ABSTRACT OF THE INVENTION In order to produce serologic variants of hepatitis B virus (HBV) surface proteins in the form of particles with substantially reduced entrapped carbohydrate content, DNA encoding the HBV variant envelope proteins was expressed in a recombinant yeast hosts which are either wild type for, or deficient in their ability to glycosylate proteins. These HBV surface proteins display the variant antigenic sites genetically encoded by the S domain of the HBV virion envelope open reading frame and contain substantially reduced levels of entrapped carbohydrate when compared with HBsAg particles produced in "wild-type" yeast cells. These particles are useful as a vaccine for both the active and passive treatment or prevention of disease and/or infection caused by HBV or other agents serologically related to HBV and as diagnostic reagents and immunogens and antigens for developing diagnostic reagents.

Affiliated with

Also associated with

Rating

Hbsag escape mutant vaccine does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hbsag escape mutant vaccine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hbsag escape mutant vaccine will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1845965