C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) A01K 67/027 (2006.01) A61K 31/675 (2006.01) A61K 38/16 (2006.01) A61K 38/45 (2006.01) A61K 39/29 (2006.01) A61K 39/42 (2006.01) C07K 14/02 (2006.01) C07K 16/08 (2006.01) C07K 16/40 (2006.01) C07K 17/00 (2006.01) C12N 9/12 (2006.01) C12N 15/51 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2500673
Applicants have identified 5 mutants associated with hepatitis B virus resistance to adefovir, a nucleotide analogue antiviral drug widely employed in the therapy of hepatitis B. In accord with this invention, reverse transcriptase mutants rtN236T, rtA181V, rtA181T and their corresponding surface antigen mutants sL173F and sL172trunc are provided. The mutant proteins, antibodies thereto and nucleic acids encoding the mutants have diagnostic value in monitoring and adjusting patient therapy with adefovir and in the therapy of patients infected with the mutants.
Les déposants ayant identifié 5 mutants associés à la résistance du virus de l'hépatite B à l'adéfovir, l'invention porte sur un médicament antiviral analogue de nucléotide largement utilisé dans la thérapie de l'hépatite B, et sur les mutants de transcriptase inverse rtN236T, rtA181V, rtA181T, sur les mutants correspondant de leurs antigènes de surface sL173F et sL172trunc. Les protéines mutantes leurs anticorps et les anis codant pour elles présentent une valeur diagnostique pour le suivi et l'ajustement de traitements de patients par l'adéfovir et pour le traitement de patients infectés par les mutants.
Delaney William E.
Xiong Xiaofeng
Delaney William E.
Gilead Sciences Inc.
Robic
Xiong Xiaofeng
LandOfFree
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