Hbv sequences

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/36 (2006.01) A61K 39/29 (2006.01) A61P 31/20 (2006.01) C07K 14/02 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2392853

The complete nucleic acid sequence of a new human hepatitis B virus genotype, provisionally named genotype G, is reported. This genotype was found with a high prevalence in patients chronically infected with HBV and residing in Europe and the USA. The present invention further relates to polypeptides encoded by said nucleic acid sequence and to antibodies recognizing said polypeptides. The present invention also relates to the use of said nucleic acid, polypeptides and antibodies in HBV diagnosis, prophylaxis and therapy.

L'invention concerne la séquence d'acides nucléiques complète d'un nouveau génotype du virus de l'hépatite B humain, nommé à titre provisoire génotype G. On a découvert que ce génotype présente une prévalence élévée chez des patients infectés chroniquement par HBV et résidant en Europe ou aux Etats-Unis. La présente invention concerne, en outre, des polypeptides codés par ladite séquence d'acides nucléiques et des anticorps reconnaissant lesdits polypeptides, ainsi que l'utilisation desdits acides nucléiques, desdits polypeptides et desdits anticorps dans le diagnostic, la prophylaxie et la thérapie du virus de l'hépatite B.

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