Hcv nucleoside inhibitor

Details Hcv nucleoside inhibitor Hcv nucleoside inhibitor

C - Chemistry, Metallurgy

07

H

C07H 19/073 (2006.01) A61K 31/513 (2006.01) A61P 31/12 (2006.01)

Patent

CA 2665049

4-Amino-1-((2R,3S,4S,5R)-5-azido-4hydroxy-5-hydroxymethyl-3-methyl-tetrahyclrofuran-2- yl)-1 H-pyrimidin-2-one(22) are hepatitis C (HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting HCV and treating HCV-mediated diseases, processes for making the compounds and synthetic intermediates employed in the process.

La présente invention concerne des 4-amino-1-((2R,3S,4S,5R)-5-azido-4-hydroxy-5-hydroxyméthyl-3-méthyl-tétrahydrofuran-2-yl)-1-H-pyrimidin-2-one(22) qui sont des inhibiteurs de la polymérase du virus de l'hépatite C (HCV). L'invention concerne également des compositions et des procédés permettant d'inhiber le HCV et de traiter les maladies induites par le HCV, des procédés de fabrication des composés et les intermédiaires synthétiques utilisés dans les procédés.

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