A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 31/70 (2006.01)
Patent
CA 2631498
The present invention relates to a pharmaceutical composition comprising a solid suspension prepared by hot melt extrusion of isobutyric acid (2R,3S,4R,5R)-5-(4-amino- 2-oxo-2H-pyrim- idin-1-yl)-2-azido-3,4-bis-iso-butyryloxy-tetrahydro-furan-2-ylmethyl ester; hydrochloride salt (I) and a polyethylene glycol (PEG)/polypropylene glycol (PPG) block copolymer.
La présente invention concerne une préparation pharmaceutique comprenant une suspension solide préparée par extrusion à l'état fondu d'isobutyrate de (2R,3S,4R,5R)-5-(4-amino- 2-oxo-2H-pyrimidin-1-yl)-2-azido-3,4-bis-iso-butyryloxy-tétrahydro-furan-2-ylméthyle; un sel de chlorhydrate (I) et un copolymère bloc polyéthylène glycol (PEG)/polypropylène glycol (PPG).
Ahmed Hashim A.
Alfredson Thomas Vernon
Birudaraj Kondamraj
Brandl Michael Thomas
Phuapradit Wantanee
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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