Hcv vaccine compositions

Details Hcv vaccine compositions Hcv vaccine compositions

A - Human Necessities

61

K

A61K 39/385 (2006.01) A61K 39/29 (2006.01) A61P 31/12 (2006.01)

Patent

CA 2391843

The present invention relates generally to an immunogenic complex comprising a charged organic carrier and a charged antigen and, more particularly, a negatively charged organic carrier and a positively charged antigen, wherein the charged antigen is a polyprotein of Hepatitis C Virus (HCV), particularly the core protein of HCV, or a fragment thereof, or a fusion protein comprising the polyprotein or a fragment thereof. The complexes of the present invention are useful, inter alia, in vaccine compositions as therapeutic and/or prophylactic agents for facilitating the induction of immune responses, and in particular a cytotoxic T-lymphocyte response, in the treatment of a disease condition which results from an HCV infection.

L'invention concerne généralement un complexe immunogénique comprenant un véhicule organique chargé et un antigène chargé et, notamment un véhicule organique à charge négative et un antigène à charge positive, l'antigène chargé étant une polyprotéine du virus de l'Hépatite C (VHC), particulièrement la protéine noyau de VHC ou un fragment de celui-ci, ou une protéine de fusion comprenant ladite polyprotéine ou un fragment de celle-ci. Les complexes de l'invention sont utiles, entre autres, dans des compositions vaccinales, en tant qu'agents thérapeutiques et/ou prophylactiques, pour faciliter l'induction de réponses immunitaires, et notamment une réponse des cellules T cytotoxiques, dans le traitement d'un état pathologique résultant d'une infection à VHC.

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