Hdac inhibitors

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C - Chemistry, Metallurgy

07

C

C07C 323/62 (2006.01) A01N 37/40 (2006.01) A01N 37/46 (2006.01) A01N 43/40 (2006.01) A01P 3/00 (2006.01) A61K 31/166 (2006.01) A61K 31/4406 (2006.01) A61K 31/455 (2006.01) A61P 31/18 (2006.01) A61P 35/00 (2006.01) C07C 231/02 (2006.01) C07C 235/60 (2006.01) C07D 213/75 (2006.01) C07D 213/82 (2006.01)

Patent

CA 2700857

This invention provides the compound having the structure wherein n is 1- 10; X is C-R11 or N, wherein R11 is H, OH, SH, F, Cl, SO2R7, NO2, trifluoromethyl, methoxy, or CO-R7, wherein R7 is alkyl, alkenyl, alkynyl, C3-C8 cycloalkyl, or aryl; R2 is H or NR3R4, wherein R3 and R4 are each independently H, C1-C6 alkyl, or C3-C8 cycloalkyl; R5 is OH or SH; and R6, R12A R13, and R14are each independently H, OH, SH, F, Cl, SO2R15, NO2, trifluoromethyl, methoxy, or CO-R15, wherein R15 is alkyl, alkenyl, alkynyl, C3-C8 cycloalkyl, or aryl, or a salt of the compound, which is useful in the treatment of tumors.

L'invention concerne un composé présentant la structure suivante, dans laquelle n représente 1-10; X représente C-R11 ou N, R11 étant H, OH, SH, F, Cl, SO2R7, NO2, trifluorométhyle, méthoxy ou CO-R7, R7 étant alkyle, alcényle, alcynyle, cycloalkyle C3-C8 ou aryle; R2 représente H ou NR3R4, R3 et R4 étant indépendamment H, alkyle C1-C6 ou cycloalkyle C3-C8; R5 représente OH ou SH; et R6, RI2A RI3 et R14 représentent indépendamment H, OH, SH, F, CI, SO2R15, NO2, trifluorométhyle, méthoxy ou CO-R15, R15 étant alkyle, alcényle, alcynyle, cycloalkyle C3-C8 ou aryle; ou un sel de ce composé, utile dans le traitement des tumeurs.

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