Hdac inhibitors

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C - Chemistry, Metallurgy

07

C

C07C 259/06 (2006.01) A61K 31/223 (2006.01) A61K 31/44 (2006.01) A61K 31/444 (2006.01) A61K 31/445 (2006.01) A61K 31/4468 (2006.01) A61K 31/496 (2006.01) A61P 35/00 (2006.01) C07C 311/19 (2006.01) C07D 209/20 (2006.01) C07D 211/26 (2006.01) C07D 211/58 (2006.01) C07D 213/56 (2006.01) C07D 241/04 (2006.01) C07D 295/088 (2006.01)

Patent

CA 2665428

Compounds of formula (I) inhibit HDAC activity, wherein A, B and D independently represent =C- or =N-; W is a divalent radical -CH=CH- or CH2CH2-; R1 is a carboxylic acid group (-COOH), or an ester group which is hydrolysable by one or more intracellular carboxyesterase enzymes to a carboxylic acid group; R2 is the side chain of a natural or non-natural alpha amino acid; z is 0 or 1; and Y, L1, and X1 are as defined in the claims.

L'invention concerne des composés de formule (I) qui inhibent l'activité HDAC, A, B et D représentant indépendamment =C- ou =N- ; W représentant un radical bivalent -CH=CH- ou CH2CH2- ; R1 représentant un groupement acide carboxylique (-COOH) ou un groupement ester hydrolysable par une ou plusieurs enzymes carboxyestérase intracellulaires en un groupement acide carboxylique ; R2 représentant la chaîne latérale d'un acide alpha aminé naturel ou non naturel ; z valant 0 ou 1 ; et Y, L1 et X1 étant tels que définis dans les revendications.

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