A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/495 (2006.01) A61K 31/44 (2006.01) C07C 259/10 (2006.01) C07D 215/20 (2006.01) C07D 233/54 (2006.01)
Patent
CA 2726734
The present invention relates to the methods of treating endocrine-regulated cancers, including hormone resistant cancers, for example. More specifically, the present invention relates to a method of increasing the sensitivity of hormone resistant cancers to hormonal therapeutic agents. In particular embodiments, the present invention concerns delivery of a histone deacetylase inhibitor and a hormone targeted drug to an individual with cancer. In specific embodiments, the histone deacetylase inhibitor and the hormone targeted drug act synergistically to treat the cancer, including by overcoming resistance to a cancer therapy.
La présente invention concerne des procédés de traitement de cancers régulés par endocrine, comprenant par exemple, des cancers résistants aux hormones. Plus spécifiquement, l'invention concerne un procédé d'augmentation de la sensibilité de cancers résistant aux hormones à des agents thérapeutiques hormonaux. Dans des modes de réalisation particuliers, la présente invention concerne l'administration d'un inhibiteur d'histone désacétylase et d'un médicament ciblant une hormone à un individu atteint de cancer. Dans des modes de réalisation spécifiques, l'inhibiteur d'histone désacétylase et le médicament ciblant une hormone agissent en synergie pour traiter le cancer, y compris en surmontant la résistance à une thérapie du cancer.
Brodie Angela
Gediya Lalji
Njar Vincent C. O.
Sabnis Gauri
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
University Of Maryland Baltimore
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