C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/55 (2006.01) A61K 38/16 (2006.01) A61P 17/06 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C12N 9/78 (2006.01) C12N 15/12 (2006.01) C12Q 1/34 (2006.01) G01N 33/573 (2006.01)
Patent
CA 2606293
This invention relates to the field of assays for compounds that interact with the binding of a PTB-containing protein, i.e. APPL (Adaptor protein containing PH domain, PTB domain and Leucine zipper motif) with histone deacetylase, in particular HDACl. Compounds identified using said assays are useful in inhibiting HDAC activity and as a medicine, in particular in the manufacture of a medicament to inhibit proliferative conditions, such as cancer and psoriasis.
L'invention concerne le domaine des essais destinés à des composés interagissant avec la liaison d'une protéine renfermant PTB, par exemple, APPL (protéine adaptatrice renfermant le domaine PH, le domaine PTB et le motif Leucine zipper) avec l'histone déacétylase, notamment la HDACl. L'invention concerne également des composés identifiés au moyen des essais, lesquels sont utiles dans l'inhibition de l'activité de la HDAC et comme médicament, notamment, dans la fabrication d'un médicament permettant d'inhiber les états prolifératifs, tels que le cancer et le psoriasis.
Andries Luc Joseph
Arts Janine
de Schepper Stefanie Helena
Vialard Jorge Eduardo
Gowling Lafleur Henderson Llp
Janssen Pharmaceutica N.v.
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