C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/30 (2006.01) C07K 14/47 (2006.01) C12N 15/12 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2679696
Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include monoclonal antibodies, and variants and fragments thereof, that specifically bind to HE4. Monoclonal antibodies having the binding characteristics of an HE4 antibody of the invention are further provided. Hybridoma cell lines that produce an HE4 monoclonal^ antibody of the invention are also disclosed herein. The compositions find use in diagnostic methods as well as in screening methods for identifying patients having an increased likelihood of having ovarian cancer. Kits comprising one or more of the disclosed HE4 monoclonal antibodies and for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an HE4 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present invention.
L'invention concerne des compositions et des procédés de diagnostic du cancer ovarien chez une patiente, et d'identification de patientes présentant une probabilité accrue de souffrir d'un cancer ovarien. Les compositions comprennent des anticorps monoclonaux, et des variantes et fragments de ceux-ci, qui se lient spécifiquement à HE4. Les anticorps monoclonaux ayant les caractéristiques de liaison d'un anticorps HE4 de l'invention sont en outre proposés. Des lignées de cellules d'hybridome qui produisent un anticorps monoclonal HE4 de l'invention sont également proposées ici. Les compositions sont utilisées dans des procédés de diagnostic ainsi que dans des procédés de criblage pour l'identification de patientes ayant une probabilité accrue de souffrir d'un cancer ovarien. L'invention concerne en outre des kits comprenant un ou plusieurs des anticorps monoclonaux HE4 décrits et la mise en pratique des procédés de l'invention. L'invention concerne également des polypeptides comprenant la séquence d'acide aminé d'un épitope de HE4 et des procédés d'utilisation de ces polypeptides dans la production d'anticorps.
Cheek Robert L.
Fischer Timothy J.
Groelke John W.
Gowling Lafleur Henderson Llp
Tripath Imaging Inc.
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