Heart abnormalities in vascular endothelial growth factor b...

G - Physics – 01 – N

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G01N 33/00 (2006.01) A01N 43/04 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61K 39/40 (2006.01) A61K 39/42 (2006.01) A61K 39/44 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 14/52 (2006.01) C12N 15/00 (2006.01) C12N 15/09 (2006.01) C12N 15/85 (2006.01) C12P 19/34 (2006.01)

Patent

CA 2363488

VEGF-B deficient animals show heart abnormalities that appear to be caused by atrioventricular (AV) conduction defects and ischemia of the myocardium. Methods are provided for screening a compound for atrioventricular conduction or ischemia modulating activity using a VEGF-B deficient non-human animal, for the treatment or alleviation of atrioventricular conduction defects or ischemia and for diagnosing heart diseases.

Les animaux carencés en facteur de croissance vasculaire endothéliale B (VEGF-B) présentent des anomalies cardiaques qui semblent être causées par des troubles de conduction auriculo-ventriculaires (AV) et une ischémie myocardique. L'invention concerne des méthodes de criblage d'un composé utilisé dans la conduction auriculo-ventriculaire ou l'activité modulatrice de l'ischémie, au moyen d'un animal non humain carencé en VEGF-B, pour traiter ou atténuer les troubles de conduction auriculo-ventriculaires ou l'ischémie et pour diagnostiquer les maladies du coeur.

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