Heart active derivatives of 1-amino-2,3-dihydroxy propane

Details Heart active derivatives of 1-amino-2,3-dihydroxy propane Heart active derivatives of 1-amino-2,3-dihydroxy propane

C - Chemistry, Metallurgy

07

D

260/602.2, 260/5

C07D 295/096 (2006.01) C07D 207/325 (2006.01)

Patent

CA 1093096

Abstract of the Disclosure Compounds of the general formula Image wherein R1 is selected from the group consisting of methyl, ethyl. propyl, methoxy, propargyloxy, cyano, allyloxy, acetyl, cyanomethyl, hydroxymethyl, CH3OCH2H2NHCOCH2O-, morpholino, pyrrolidino and pyrrolyl, R2 and R3 are the same or different and are each selected from the group consisting of hydrogen alkoxyalkoxy, alkyl, cyano, hydroxy, halogen, alkoxy, and hydroxymethyl provided that R2 and R3 are not both hydrogen, n is an integer 2, 3 or 4, and X is -O- or -S-. These compounds find pharmaceutical use in the treatment of cardiovascular disorders.

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