Heart valve prosthesis and methods of manufacture and use

A - Human Necessities – 61 – F

Patent

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A61F 2/24 (2006.01)

Patent

CA 2614431

A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

L'invention porte sur une prothèse de valvule cardiaque dotée d'un cadre à plusieurs niveaux auto-déployable, soutenant un corps de valvule comprenant une jupe et une pluralité de valves d'adaptation. Le cadre passe d'une configuration d'administration contractée permettant l'administration transluminale percutanée, à une configuration déployée présentant une forme de sablier asymétrique. Cette jupe de corps de valvule et les valves sont conçues de manière que le centre d'adaptation puisse être sélectionné afin de réduire les forces horizontales exercées sur les rebords de la valvule, et afin de répartir et transmettre efficacement des forces le long des valves et sur le cadre. Dans une alternative, le corps de valvule peut être utilisé en tant que prothèse de valvule de substitution à implantation chirurgicale.

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