C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/22 (2006.01) C12N 1/16 (2006.01) C12N 1/19 (2006.01) C12N 9/16 (2006.01) C12N 15/09 (2006.01) C12N 15/55 (2006.01) C12N 15/63 (2006.01) C12Q 1/34 (2006.01)
Patent
CA 2453872
According to the invention, the desoxyribonuclease with increased thermolability is a variant, by way of amino acid substitution, of bovine pancreatic desoxyribonuclease I. The variant protein retains desoxyribonuclease activity. Moreover, the specific desoxyribonuclease activity of the variant of bovine pancreatic desoxyribonuclease I is approximately zero units per mg of protein following heating of the variant of bovine pancreatic desoxyribonuclease I for about 5 min at a temperature below 95°C. In addition, the variant of bovine pancreatic desoxyribonuclease I has no measurable ribonuclease activity.
Engel Wolf-Dieter
Engh Richard
Hoffmann Artur
Kirschbaum Thomas
Mueller Rainer
F.hoffmann-La Roche Ag
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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