Heat sealable membrane for transdermal drug release

A - Human Necessities – 61 – L

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128/104, 18/12

A61L 15/44 (2006.01) A61K 9/70 (2006.01) A61M 35/00 (2006.01) A61M 37/00 (2006.01) C08G 18/61 (2006.01)

Patent

CA 1323148

HEAT SEALABLE MEMBRANE FOR TRANSDERMAL DRUG RELEASE ABSTRACT A transdermal drug delivery system, is provided which includes, in combination, an impermeable backing member, a release rate controlling membrane and a reservoir containing a medicinally active ingredient; the improvement in such system is based on the fact that said membrane is heat and pressure sealed to said backing without the u e of a separate adhesive and is formed of a substantially linear block copolymer which is a reaction product of an amino functional polydiorganosiloxane which forms soft segments in said reaction product ant a diisocyanate which forms "hard" segments, said copolymer having a glass transition temperature between 50°C. and 200°C., said soft segments comprising from 60 to 90 percent by weight, based on the weight of said copolymer.

593747

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