Heat shock protein gp96 vaccination and methods of using same

Details Heat shock protein gp96 vaccination and methods of using same Heat shock protein gp96 vaccination and methods of using same

A - Human Necessities

61

K

A61K 38/16 (2006.01) A61K 35/12 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2718884

The invention provides a tumor cell genetically modified to express a nucleic acid encoding a secreted form of a heat shock protein (hsp) gp96 polypeptide. The invention also provides a method of stimulating an immune response to a tumor by administering a tumor cell genetically modified to express a nucleic acid encoding a secreted form of a gp96 polypeptide.

Cette invention concerne une cellule tumorale génétiquement modifiée pour exprimer un acide nucléique codant pour une forme sécrétée d'un polypeptide de la protéine de choc thermique (hsp) gp96. L'invention concerne également un procédé de stimulation d'une réponse immunitaire à une tumeur par administration d'une cellule tumorale génétiquement modifiée pour exprimer un acide nucléique codant pour une forme sécrétée d'un polypeptide de gp96.

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