Heat sterilization of glucocorticosteroids

Details Heat sterilization of glucocorticosteroids Heat sterilization of glucocorticosteroids

A - Human Necessities

61

K

A61K 9/10 (2006.01)

Patent

CA 2569549

The present invention provides a method for the sterilization of a labile glucocorticosteroid, which method comprises heat-treating by moist heat the labile glucocorticosteroid in the form of a suspension for a sterilizing- effective time. The methods and compositions according to the invention are useful as therapeutic tools to prevent, reverse, and/or reduce the symptoms of allergic and/or inflammatory conditions in a mammalian patient. The invention also provides methods and compositions, which may be manipulated and fine- tuned to fit the condition(s) to be treated while producing fewer side effects.

L'invention concerne un procédé pour stériliser un glucocorticostéroïde instable. Ce procédé consiste à préchauffer à l'aide d'une chaleur humide le glucocorticostéroïde instable sous forme de solution, pendant une durée efficace en termes de stérilisation. Les procédés et compositions selon l'invention servent d'outils thérapeutiques pour empêcher, faire rétrocéder et/ou réduire les symptômes d'états allergiques et/ou inflammatoires chez un patient mammalien. La présente invention se rapporte en outre à des procédés et des compositions qui peuvent être modifiés et affinés pour s'adapter aux états à traiter, tout en engendrant moins d'effets secondaires.

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