Heavy metal salts of hyaluronic acid useful as antimicrobial...

C - Chemistry – Metallurgy – 08 – B

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C08B 37/08 (2006.01) A01N 43/16 (2006.01) A61K 31/28 (2006.01)

Patent

CA 1291123

HEAVY METAL SALTS OF HYALURONIC ACID AND THEIR USE AS ANTIMICROBIAL AGENTS ABSTRACT OF THE DISCLOSURE Heavy metal salts of hyaluronic acid have been pre- pared. In particular, this invention is directed to silver, gold, cerium and tungsten salts of hyaluronic acid. These heavy metal salts of hyaluronic acid are useful as antimicrobial agents. Gold hyaluronate may also be used to treat arthritis. This invention also concerns methods of making the silver salt of hyaluronic acid as well as compositions containing silver hyaluronate or gold hyaluronate. The invention also concerns composition containing heavy metal salts having radioactively labelled hyalu- ronate moieties.

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