Hedgehog antagonists, methods and uses related thereto

Details Hedgehog antagonists, methods and uses related thereto Hedgehog antagonists, methods and uses related thereto

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 31/4025 (2006.01) C07J 69/00 (2006.01) C07J 71/00 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2425356

The present application is directed to compositions and methods for inhibiting angiogenesis and treating or preventing unwanted cell proliferation, including tumors, by inhibiting the hedgehog pathway, e.g., with an antagonist of the hedgehog pathway such as those disclosed herein.

La présente invention concerne des compositions et des procédés permettant, d'une part, d'inhiber l'angiogénèse et, d'autre part, de traiter et d'empêcher une prolifération cellulaire non souhaitée, y compris les tumeurs, par inhibition de la voie Hedgehog, par exemple, à l'aide d'un antagoniste de la voie Hedgehog, tel que ceux qui sont décrits dans la présente invention.

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