Hedgehog fusion proteins and uses

Details Hedgehog fusion proteins and uses Hedgehog fusion proteins and uses

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/17 (2006.01) C07K 14/46 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2390166

A fusion polypeptide is described having the amino acid sequence X-Y-Z, or a portion thereof, comprising the amino acid sequence of a hedgehog (X); Y is an optional linker moiety; and Z is a polypeptide comprising at least a portion of a polypeptide other than hedgehog. It is preferred that X is a human hedgehog. Mutants of hedgehog are also described.

L'invention concerne un polypeptide de fusion comprenant une séquence d'acide aminé X-Y-Z, ou une partie de cette séquence, comprenant la séquence d'acide aminé d'une protéine hérisson (X); Y est une fraction de liaison facultative; et Z est un polypeptide comprenant au moins une partie d'un polypeptide autre que hérisson. Il est préférable que X soit une protéine hérisson humaine. L'invention concerne également des mutants de protéines hérisson.

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