Hedgehog interacting proteins and uses related thereto

Details Hedgehog interacting proteins and uses related thereto Hedgehog interacting proteins and uses related thereto

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) C07K 14/46 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2266429

The present invention concerns the discovery of a new family of hedgehog binding proteins, referred to herein as "hedgehog interacting proteins" or "HIPs", which are demonstrated to bind to hedgehog polypeptides with high affinity. As described herein, the vertebrate HIP proteins exhibit spatially and temporally restricted expression domains indicative of important roles in hedgehog-mediated induction.

La présente invention concerne la découverte d'une nouvelle famille de protéines de liaison de type hérisson ou "protéines d'interaction hérisson" (par ailleurs "HIP" pour "hedgehog interacting proteins"), dont on a démontré qu'elle présentent une affinité élevée de liaison avec les polypeptides de type hérisson. Comme le précise la description, les protéines HIP des vertébrés présentent des domaines d'expression spatialement et temporellement restreints reflétant les rôles importants dans l'induction de la médiation à hérisson.

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