C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/06 (2006.01) A61K 38/05 (2006.01) A61K 38/08 (2006.01) A61P 25/28 (2006.01) C07K 5/06 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2476292
Helical peptidomimetic compounds as inhibitors of beta-amyloid production are provided. These inhibitors preferably inhibit intramembrane proteases, notably aspartyl secretases involved in the enzymatic cleavage of amyloid precursor protein (APP) to yield amyloid-.szlig. peptide. Methods are provided for making a medicament containing the compounds and for administering the compounds to treat .szlig.-amyloid-associated diseases, notably Alzheimer's disease.
L'invention concerne des composés peptidomimétiques hélicoïdaux utilisés en tant qu'inhibiteurs de la production de béta-amyloïdes. Ces inhibiteurs inhibent, de préférence, les protéases intramembranaires, et notamment les aspartyl sécrétases associées au clivage enzymatique de la protéine précurseur amyloïde (APP) afin d'obtenir un peptide ss-amyloïde. L'invention concerne des méthodes de fabrication d'un médicament contenant ces composés, et des méthodes d'administration des composés pour traiter les maladies associées au ss-amyloïde, notamment la maladie d'Alzheimer.
Brigham And Women's Hospital Inc.
Smart & Biggar
LandOfFree
Helical peptidomimetics does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Helical peptidomimetics, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Helical peptidomimetics will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1686675