Helicobacter pylori-colonized mongolian gerbil, process for...

A - Human Necessities – 01 – K

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Details

A01K 67/00 (2006.01) A01K 67/027 (2006.01) A61K 49/00 (2006.01) C12N 1/20 (2006.01) C12Q 1/04 (2006.01)

Patent

CA 2182805

Helicobacter pylori-colonized Mongolian gerbils prepared by oral inoculation of a broth culture obtained by liquid culture of Helicobacter pylori, to the Mongolian gerbils for intragastric colonization of Helicobacter pylori. These Mongolian gerbil models are useful for screening the therapeutic efficacies of drugs against Helicobacter pylori, as well as elucidation of pathology of Helicobacter pylori disease in humans. Moreover, the medium of the present invention for isolating Helicobacter pylori, which is supplemented with vancomycin, trimethoprim, amphotericin B, polymyxin B and 2,3,5-triphenyltetrazolium chloride, enables selective and efficient detection of Helicobacter pylori colonized in Mongolian gerbils which have microorganisms living in stomach. A combined use of the above-mentioned Mongolian gerbil models and the medium for isolating Helicobacter pylori enables screening of an anti- Helicobacter pylori substance at an animal level, thereby enabling accurate prediction of clinical effects of the anti-Helicobacter pylori substance.

On colonise une gerbille de Mongolie par Helicobacter pylori en administrant par voie orale à cette gerbille de Mongolie une culture liquide d'Helicobacter pylori pour provoquer une colonisation de l'estomac. Ce modèle animal est très utile pour une évaluation préliminaire de l'effet thérapeutique de médicaments sur Helicobacter pylori et pour élucider les effets pathologiques de Helicobacter pylori chez l'homme. Un milieu pour séparer Helicobacter pylori contenant de la vancomycine, de la triméthoprime, de l'amphotéricine B, de la polymixine B et du chlorure de 2,3,5-triphényltétrazolium permet de détecter d'une manière sélective et efficace les bactéries Helicobacter pylori avec lesquelles les gerbilles de Mongolie colonisées par des micro-organismes gastriques ont été infectées. La combinaison du modèle animal et du milieu de séparation permet une sélection préliminaire de substances actives contre Helicobacter pylori au niveau animal et une prévision précise des effets cliniques de ces substances.

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