C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) C07K 14/205 (2006.01) C07K 16/12 (2006.01) G01N 33/543 (2006.01) G01N 33/569 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2192312
The application discloses a nickel binding protein and its encoding DNA isolated from Helicobacter pylori. This organism is the primary cause of chronic gastritis and ensuing peptic ulcers, and has been implicated in stomach cancer. The nickel binding protein is useful to inhibit assembly of active ureases, the enzymes responsible for the pathogenic features of the bacterium. Potential uses include as a vaccine a diagnosctic, a drug target, and a therapy in itself.
La présente invention concerne une protéine de liaison de nickel et son ADN codant, protéine qui a été isolée de l'Hélicobacter Pylori. Cet organisme, qui est la cause première des gastrites chroniques et des ulcères peptiques qui s'ensuivent, a été impliqué dans le cancer gastrique. Cette protéine de liaison de nickel permet de bloquer la synthèse des uréases actives, qui sont les enzymes responsables des aspects pathogènes de la bactérie. Cette protéine peut potentiellement être utilisée comme vaccin, agent diagnostique, cible pharmaceutique et comme thérapie proprement dite.
Gilbert-Rothstein Joanne V.
Plaut Andrew G.
Wright Andrew
Gilbert-Rothstein Joanne V.
New England Medical Center Hospitals Inc.
Plaut Andrew G.
Smart & Biggar
Trustees Of Tufts College
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