C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 39/02 (2006.01) A61K 39/106 (2006.01) A61P 31/04 (2006.01) C07H 21/00 (2006.01) C07K 14/195 (2006.01) C07K 17/00 (2006.01) C12P 19/34 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2131729
Helicobacter pylori is known to cause or be a cofactor in type B gastritis, peptic ulcers, and gastric tumors. In both deve-loped and developing countries, a high percentage of people are infected with this bacterium. The present invention relates gen-erally to certain H. pylori proteins, to the genes which express these proteins, and to the use of these proteins for diagnostic and vaccine applications. Specifically, molecular cloning, nucleotide, and amino acid sequences for the H. pylori cytotoxin (CT), the "Cytotoxin Associated Immunodominant" (CAI) antigen, and the heat shock protein (hsp60) are described herein.
Bugnoli Massimo
Covacci Antonello
Macchia Giovanni
Rappuoli Rino
Telford John
Biocine S.p.a.
Borden Ladner Gervais Llp
Novartis Vaccines And Diagnostics S.r.l.
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