A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/106 (2006.01) A61P 31/04 (2006.01) C07K 14/205 (2006.01) C12N 1/20 (2006.01) C12N 9/10 (2006.01) C12N 15/31 (2006.01)
Patent
CA 2415586
Helicobacter pylori can be manipulated at a genetic level to prevent the synthesis of auto-reactive LPS, without destroying the physical integrity or function of the bacterial outer membrane. The bacterium is particularly useful for preparing cellular vaccines which do not induce antibodies which cross- react with self epitopes. Cellular H.pylori vaccines are provided which comprise mutant H.pylori which either does not express LPS or, preferably, expresses a mutant form of LPS.
L'invention concerne la manipulation génétique de Helicobacter pylori afin d'empêcher la synthèse des lipopolysaccharides (LPS) auto-réactifs sans détruire l'intégrité physique ou la fonction de la membrane extérieure bactérienne. Cette bactérie est particulièrement utile dans la préparation de vaccins cellulaires n'induisant pas d'anticorps à réaction croisée avec des auto-épitopes. L'invention concerne également des vaccins cellulaires contre H.pylori comprenant un H.pylori mutant n'exprimant pas les LPS ou exprimant, de préférence, une forme mutante de LPS.
Del Giudice Guiseppe
Rappuoli Rino
Borden Ladner Gervais Llp
Chiron S.p.a.
Del Giudice Guiseppe
Rappuoli Rino
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