Helix 12 directed non-steroidal antiandrogens

Details Helix 12 directed non-steroidal antiandrogens Helix 12 directed non-steroidal antiandrogens

C - Chemistry, Metallurgy

07

D

C07D 233/42 (2006.01) A61K 31/4166 (2006.01) A61K 31/4178 (2006.01) A61K 31/5377 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2612398

Compounds having the structure or their salts are used to treat or reduce the likelihood of acquiring androgen-dependent diseases, such as prostate cancer, benign prostatic hyperplasia, polycystic ovarian syndrome, acne, hirsutism, seborrhea, androgenic alopecia and male baldness. The compounds can be formulated together with pharmaceutically acceptable diluents or carriers or otherwise made into any pharmaceutical dosage form. Combinations with other active pharmaceutical agents are also disclosed.

L'invention porte sur des composés de structure suivante et sur leurs sels, utilisés pour traiter ou réduire la probabilité d'acquérir des maladies dépendantes des androgènes telles que: le cancer de la prostate, l'hyperplasie bénigne de la prostate, le syndrome des ovaires polykystiques, l'acné, l'hirsutisme, la séborrhée, l'alopécie androgène et la calvitie masculine. Lesdits composés peuvent être associés à des diluants ou excipients pharmacocompatibles, ou autrement produits en tant que formes posologiques. On peut également prévoir leur combinaison avec d'autres principes pharmaceutiques actifs.

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