Helix 12 directed steroidal pharmaceutical products

C - Chemistry – Metallurgy – 07 – J

Patent

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Details

C07J 1/00 (2006.01) A61K 31/565 (2006.01) A61K 31/58 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2551737

Compounds having the structure or their salts: are used to treat or reduce le likelihood of acquiring androgen-dependent diseases, such as prostate cancer, benign prostatic hyperplasia, polycystic ovarian syndrome, acne, hirsutism, seborrhea, androgenic alopecia and male baldness. They can be formulated together with pharmaceutically acceptable diluent or carrier or otherwise made into any pharmaceutical dosage form. Some of these compounds having tissue- specific antiandrogenic activity and tissue-specific androgenic activity can be used to treat or reduce the risk of developing diseases related to loss of androgenic stimulation. Combinations with other active pharmaceutical agents are also disclosed.

Cette invention se rapporte à des composés représentés par la structure (I), ou à leurs sels, qui sont utilisés pour traiter ou réduire le risque de contracter des maladies dépendantes des androgènes, telles que le cancer de la prostate, l'hyperplasie bénigne, le syndrome ovarien polycystique, l'acné, l'hirsutisme, la séborrhée, l'alopécie androgénique et la calvitie chez l'homme. Ces composés peuvent être formulés conjointement avec un diluant ou un excipient acceptable sur le plan pharmaceutique ou alors fabriqués sous une forme galénique. Certains de ces composés possédant une activité anti-androgène spécifique des tissus et une activité androgène spécifique des tissus peuvent être utilisées pour traiter ou réduire le risque de développer des maladies liées à la perte de stimulation androgène. Des combinaisons avec d'autres agents pharmaceutiques actifs sont également décrites.

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