Helper dependent adenovirus vectors based on site-specific...

Details Helper dependent adenovirus vectors based on site-specific... Helper dependent adenovirus vectors based on site-specific...

C - Chemistry, Metallurgy

12

N

C12N 15/861 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2363063

This invention provides helper-dependent adenovirus cloning vectors and helper adenoviruses, and methods for mak- ing and using such preparations, wherein the helper adenoviruses contain recombinase target sites that are useful in reducing the level of contamination of helper virus in helper-dependent adenovirus vector preparations.

Cette invention concerne des vecteurs de clonage adénoviraux dépendant d'assistants et des adénovirus assistants, ainsi que des méthodes d'obtention de telles préparations Les adénovirus assistants renferment des sites cibles de la recombinase. Ils permettent de réduire le niveau de contamination de virus assistants dans des préparations de vecteurs adénoviraux dépendant d'assistants.

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