Hematology control composition for leukocyte analogs; and...

Details Hematology control composition for leukocyte analogs; and... Hematology control composition for leukocyte analogs; and...

G - Physics

01

N

G01N 33/96 (2006.01) A61K 35/14 (2006.01) G01N 15/12 (2006.01) G01N 33/49 (2006.01)

Patent

CA 2129832

ABSTRACT OF THE DISCLOSURE A hematology control product comprising leukocyte analogs is described. The analogs comprise red blood cells which simulate at least two physical properties of human leukocytes. A method for making leukocyte analogs from blood cells having desixed physical properties is also described. The process comprises expanding the cell volume, changing the hemoglobin content of the cell and fixing the cell. Generally the monocyte and lymphocyte analogs leak hemoglobin from the cell while the eosinophil analog has the hemoglobin precipitated in the cell. A further method is described to use the control product to determine whether an automatic instrument is operating within manufacturer's specification.

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