C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/0789 (2010.01) A61K 35/14 (2006.01) A61K 35/28 (2006.01) A61P 7/00 (2006.01)
Patent
CA 2336490
Cell compositions consisting essentially of mammalian hematopoietic CXCR4+ stem and progenitor cells capable to migrate in response to stromal-derived factor 1 (SDF-1) and/or capable to adhere to stromal cells in response to an adhesion-inducing agent, are provided for clinical transplantation. Hematopoietic CXCR4-/low stem and progenitor cells can be converted into CXCR4+ cells by stimulation with a suitable agent. The composition consists preferably of human CD38-/low CXCR44 cells.
L'invention concerne des compositions cellulaires consistant essentiellement en cellules hématopoïétiques CXCR4?+¿ souches et parentes, capables de migrer en réponse au facteur 1 dérivé de cellules stromales (SDF-1) et/ou capables d'adhérer à des cellules stromales en réponse à un agent induisant l'adhésion cellulaire, destinées à être utilisées dans la transplantation clinique. Les cellules hématopoïétiques CXCR4?-/inférieur¿ souches et parentes peuvent être converties en cellules CXCR4?+¿ par stimulation à l'aide d'un agent approprié. La composition consiste, de préférence en cellules CD38?-/inférieur¿ CXCR4+.
Lapidot Tsvee
Peled Amnon
Borden Ladner Gervais Llp
Yeda Research And Development Co. Ltd.
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