C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/08 (2006.01) A61K 35/14 (2006.01) A61K 35/28 (2006.01) A61K 35/50 (2006.01) A61K 48/00 (2006.01) C12N 5/06 (2006.01) C12N 5/10 (2006.01) A61K 35/12 (2006.01)
Patent
CA 2181547
The application concerns a method for the ex vivo expansion of hematopoietic cells, including hematopoietic stem and progenitor cells, using endothelial support cells in an artificial capillary system (ACS). The invention also concerns improved bone marrow transplantation methods. Also, the application concerns a method for enhancing the ex vivo expansion of hematopoietic cells by coating the capillaries of an ACS with a suitable coating reagent. A method for transducing ex vivo expanding hematopoietic cells, including hematopoietic stem and progenitor cells, with packaged recombinant retrovirus vectors is also provided.
L'invention concerne un procédé permettant l'expansion ex vivo de cellules hématopoïétiques, y compris des cellules souches et mères hématopoïétiques, au moyen de cellules de support endothéliales, dans un système de capillaires artificiel (ACS). L'invention concerne également des procédés améliorés de greffe de moelle osseuse. Est également décrit un procédé permettant la stimulation de l'expansion ex vivo de cellules hématopoïétiques, consistant à revêtir les capillaires du système de capillaires artificiel avec un réactif approprié. L'invention concerne en outre un procédé de transduction ex vivo de cellules hématopoïétiques en expansion, y compris des cellules hématopoïétiques souches et mères, avec des vecteurs rétroviraux de recombinaison à encapsulation.
Davis Thomas A.
Kidwell William R.
Lee Kelvin P.
Cellco Inc.
Davis Thomas A.
Kidwell William R.
Lee Kelvin P.
Mbm & Co.
LandOfFree
Hematopoietic cell expansion and transplantation methods does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Hematopoietic cell expansion and transplantation methods, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hematopoietic cell expansion and transplantation methods will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1805776