C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) A61K 35/12 (2006.01) A61K 35/14 (2006.01) A61K 35/28 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 16/28 (2006.01) C12Q 1/24 (2006.01) G01N 33/554 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2202472
An isolated and purified glycoprotein and functional analogs are disclosed. The glycoproteins are characterized by being expressed on at least primitive hematopoietic cells, and being a ligand for L-selectin. The binding of ligand to L-selectin is not inhibitied by anti-CD34 antibodies nor by MECA 79 monoclonal antibody.
L'invention concerne une glycoprotéine isolée et purifiée et des analogues fonctionnels. Les glycoprotéines sont caractérisées en ce qu'elles sont exprimées sur au moins des cellules hématopoïétiques primitives, et qu'elles constituent un ligand pour L-sélectine. La liaison du ligand sur L-sélectine n'est pas empêchée par des anticorps anti-CD34 ni par l'anticorps monoclonal MECA 79.
Borden Ladner Gervais Llp
University Of South Florida
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