C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/078 (2010.01) C12N 5/071 (2010.01) C12N 5/0735 (2010.01) A61K 35/12 (2006.01) A61K 48/00 (2006.01) A61P 37/02 (2006.01) C12N 5/10 (2006.01) C12Q 1/02 (2006.01)
Patent
CA 2469483
This invention provides a system for producing cells of the hematopoietic lineage from embryonic stem cells. Differentiation is conducted in the presence of hematogenic cytokines and other factors listed in the disclosure. The cell population that is obtained is remarkably enriched in CD45 +ve cells, a marker of early hematopoietic precursor with self-renewing capacity. Including a bone morphogenic protein during the differentiation process enhances the ability of the cell population to form secondary colonies. Because of the enormous replicative capacity of embryonic stem cells, this provides an important new commercial source of hematopoietic cells.
La présente invention concerne un système permettant de produire des cellules de la lignée hématopoïétique à partir de cellules souches embryonnaires. La différenciation est effectuée en présence de cytokines hématogènes et d'autres facteurs mentionnés dans le descriptif de l'invention. La population cellulaire obtenue est remarquablement enrichie en cellules contenant CD45, un marqueur d'un précurseur hématopoïétique précoce capable de s'auto-renouveler. L'intégration d'une protéine morphogénétique osseuse lors du processus de différenciation améliore la capacité de la population cellulaire à former des colonies secondaires. En raison de la très grande capacité de réplication des cellules souches embryonnaires, ce système représente une importante nouvelle source commerciale de cellules hématopoïétiques.
Bhatia Mickie
Ferber Iris A.
Madrenas Joaquin
Majumdar Anish Sen
Geron Corporation
Robarts Research Institute
Smart & Biggar
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